Retina-Vitreous
2010 , Vol 18 , Num 4
Treatment of Dry Age-Related Macular Degeneration
1Ankara Numune Eğitim ve Araştırma Hastanesi, 2. Göz Kliniği, Ankara, Doç. Dr.2Ankara Numune Eğitim ve Araştırma Hastanesi, 2. Göz Kliniği, Ankara, Asist. Dr Age related macular degeneration (ARMD) is the third most common reason for legally blindness in the world. It is known that it currently exists between 30 and 50 million people around the world and is estimated that will have doubled by the end of the coming decade. It is important to know the relation between changeable risk factors of ARMD, which are smoking, diet, obesity, systemic diseases and environmental factors and the disease is important in terms of preventing and decreasing the progression in the disease. Another risk factor is the fact that the necessary dietary supplements can not be consumed in certain diets. Lack of antioxidants like lutein, zeaxanthin, cryptoxanthin, alpha-carotene, and beta-carotene together with vitamins C, D, E, and zinc, copper, selenium, magnesium trace minerals play a role in ARMD pathogenesis. In order to prevent or decrease the progression in ARMD and to live a healthy life, people especially over 55 years should be suggested to keep away from sunlight, a life without smoking, regular physical activity, controlled weight, blood pressure and cholesterol, decreased fat and sugar consumption and cunsumption of green vegetables, walnut and fruit, together with fish once or twice a week. If ARMD is diagnosed in an early stage, 10mg/day lutein and 500-1000 mg/day omega-3 intake is suitable. If there is advanced stage ARMD in one eye, intense antioxidan supplement may be thought about as mentioned in AREDS studies. Antioxidant, vitamin and mineral supplements are good in terms of protecting the other eye, but it should be kept in mind that these treatments also have their side effects. Laser treatment in eyes with drusen, Rheopheresis, Implantable miniature telescope and macular translocation have been tried for ARMD treatment; however, have not proved effective. Research on Glatiramer Acetate (Vaccination With Copaxone), Fenretinide, Eculizumab (Soliris), ARC1905 (Anti-C5 Aptamer), RN6G, Photobiomodulation, OT-551 and AL-8309B Antioxidant Eye Drops, Sirolimus (Rapamycin), Encapsulated Cell Technology Implant (Cilier Nörotrofik Faktör) ve RPE Transplantation (Retinal Replacement Therapy) is still being conducted. Along with these, there will be new treatment alternatives together with the developments related to pathophysiology, immunology and genetic sciences. Keywords : Age-related macular degeneration, dry ARMD, treatment