2M.D. Asistant Professor, Recep Tayyip Erdoğan Medical School, Physical Medicine and Rehabilitation, Rize/TURKEY
3M.D. Professor, Recep Tayyip Erdoğan Medical School, Department of Ophthalmology, Rize/TURKEY Purpose: To compare the retinal nerve fiber layer (RNFL) thickness of patients with low serum 25-hydroxyvitamin D (25OHD) with those of healthy controls.
Materials and Methods: Forty eyes of 40 premenopausal women with low serum 25OHD (patient group) and 40 eyes of 40 age- and sex-matched healthy subjects (control group) were included in the study. Disc area (DA), rim area (RA), central subfield thickness (CST), cube volume (CV), cube average thickness (CAT), average RNFL thickness, and peripapillary RNFL thicknesses of temporal, nasal, inferior, and superior quadrants were determined by Cirrus HD spectral-domain optical coherence tomography (OCT) in each participant.
Results: Although CST and CAT were thinner in the patient group than in the control group, the difference did not reach statistical significance (p1=0.019 and p2=0.025, respectively). On the other hand, CST had a significant correlation with serum 25OHD levels (r1=0.371, p1<0.001).
Conclusions: We demonstrated that although low serum 25OHD levels caused CST and CAT thinning, this thinning was not statistically significant. However, there was a relationship between the CST and serum 25OHD levels. Further studies with larger sample sizes are warranted.
Keywords : 25-Hydroxyvitamin D, spectral-domain, optical coherence tomography