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M.D. Professor, Ankara University Faculty of Medicine, Department of Ophthalmology, Ankara/TURKEY Polypoidal choroidal vasculopathy, retinal angiomatous proliferation and large pigment epithelial detachment are different clinical entities that negatively affect the treatment results in the patients with agerelated macular degeneration. In this case, the correct diagnosis is primarily necessary to provide adequate treatment. Nowadays, with the development of new imaging techniques, it is possible to diagnose these different clinical entities by using optical coherence tomography, fluorescein angiography and indocyanine green angiography. However, the first condition for a correct diagnosis is the presence of clinical suspicion. All patients who are resistant to existing treatment or with lesions that do not overlap with age-related macular degeneration should be approached with clinical suspicion and diagnosis should be confirmed by indocyanine green angiography. Appropriate treatment for the definitive diagnosis should be chosen, if necessary, combination therapy, high dose applications, switching to different molecules should be considered. Keywords : Fluorescein angiography, indocyanine green angiography, large pigment epithelium detachment, optical coherence tomography, polypoidal choroidal vasculopathy, retinal angiomatous proliferation