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SSK, Ankara 1. Göz Kliniği We investigated the efficacy of low dose cyclosporin-A (CsA) in ocular Behçet's disease in 67 eyes of 38 patients. Twenty (20) patients were given CsA alone and 18 were given in combination with low dose prednisone. Initial dose of CsA was 5 mg/kg/day in all patients. This dosage was gradually reduced to a maintenance level of 3 mg/kg/day. Ocular inflamation substantially resolved within the first two weeks of treatment. No ocular attacks ocurred in 39 eyes (%58.2) Visual acuity improved in 26 eyes(%38.8), didn't change in 20(%29.9) and deteriorated in 21(%31.3). Thus visual acuity remained stable or improved in %68.7 of eyes over the course of therapy. No difference was observed in the improvement or stabilization of the visual acuity between the patients treated with CsA alone an the patients treated with combined CsA and prednisone (P>0.05). We saw that the use of low dose CsA is effective in controlling the acute inflammation and reducing the frequency of ocular attacks in Behçet's disease. Keywords : Behçet's disease, ocular involvement, Cyclosporin-A