2Uz. Dr., S.B. Isparta Devlet Hastanesi, Nöroloji Kliniği, Isparta - TÜRKİYE Purpose: To compare the choroidal thickness (CT) and retinal nerve fi ber layer (RNFL) thickness in patients with migraine and healthy controls, using wide fi eld en face optical coherence tomography (OCT).
Materials and Methods: This prospective study included 36 eyes of 36 patients in the migraine group and 36 healthy cases as control subjects. The RNFL thickness was analyzed with OCT protocol while CT was analyzed with Enhanced depth imaging (EDI) protocol in all subjects. CT was measured at the fovea, 1500 ?m nasal and 1500 ?m temporal to the fovea in a horizontal section. The values were compared in both groups. T-test was used as statistical analysis. p <0.05 values considered statistically signifi cant.
Results: The mean RNFL thickness (?m) in the eyes of patients with migraine for temporal-upper (TU) (78.1 ± 7.2), temporal-lower (TL) (63.7 ± 5.) and infero-nasal (IN) (100.5 ± 10.8) sectors was signifi cantly thinner than the control group TU (89.3 ± 7.8), TL (75.9 ± 7.4) and IN (116.3 ± 12.1) sectors (p=.000). The mean RNFL thickness (?m) was signifi cantly thinner than in migraine patients (100.5 ± 9.1) compared to controls (109.6 ± 12.1). CT (?m) was signifi cantly thinner in the eyes of patients with migraine at the fovea (270.47 ± 36.29 ?m), temporal (251.72 ± 35.09) and nasal (237.83 ± 32.86) region of the fovea (p< 0.05) in comparison with control group (290.44 ± 39.27, 270.47 ± 38.51, 256.97 ± 35.68).
Conclusions: Migraine leads to thinning of the TL,TU, IN and mean RNFL thickness and CT.
Keywords : Migraine, optical coherence tomography, choroidal thickness, retinal nerve fi ber layer thickness