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¹Ophthalmologist, Bingol City Hospital, Department of Ophthalmology, Bingol, Turkey
²Ophthalmologist, Ercis City Hospital,Department of Ophthalmology, Van Turkey
³Associate Prof., Kayseri Mayagoz Hospital,Department of Ophthalmology, Kayseri, Turkey
⁴Associate Prof., Ankara Ulucanlar Training and Research Hospital, Department of Ophthalmology, Ankara, Turkey DOI : 10.37845/ret.vit.2020.29.63 We aimed to present a patient with complete resolution of the vacuole sign, which is a previously defi ned optical coherence tomography (OCT) finding of central serous chorioretinopathy (CSC), after injection of intravitreal bevazicumab (IVB). A 38-year old male patient presented with the complaint of decreased vision in the left eye. Fundus examination revealed well-defined diffuse serous retinal detachment in the macula of the left eye and the OCT section through that area revealed a serous detachment area, hyper-reflective fibrinous material accumulation and two vacuolar structures visible as hyporefl ective spaces. In this coexistence of the fi ndings, a recurrent CSC episode accompanied by fibrin accumulation was considered and an IVB injection was performed. One month later, OCT revealed complete resolution of the subretinal fluid and vacuole sign in addition to irregularities in RPE and the ellipsoid zone. IVB injection may be used as an effective treatment in CSC associated with fibrin accumulation and could have an important role in the resolution of the vacuole sign which consists of fibrin accumulation. Keywords : Central serous chorioretinopathy, Intravitreal bevacizumab, Vacuole sign