Materials and Methods: This cross-sectional, comparative clinical study included 25 eyes of 25 RP cases and 25 eyes of 25 healthy volunteers. After the routine ophthalmological examination, optical coherence tomography angiography (OCTA) and pattern electroretinography (pERG) examinations were performed.

Results: In the optic nerve head retinal nerve fiber layer (RNFL) thickness analysis, the thickness of lower temporal quadrant and mean RNFL thickness values were found to be significantly lower in the patient group when compared to the control group (respectively; p=0.001; p=0.003). In pERG analysis, it was found that there was a prolongation in implicit time and a decrease in wave amplitudes were detected in P50 and N95 waves in patients with RP (p<0.05 for all values).Radial peripapillary capillary (RPC) mesh vascular density (VD) was significantly lower in all quadrants in the RP group (p<0.001). A correlation was found between best corrected visual acuity (BCVA) and upper nasal quadrant RNFL thickness.

Conclusion: In RP patients, the vascular changes can cause optic nerve damage and decrease in BCVA. To identify changes in both vascular and nerve fiber structures around the disc using OCTA may contribute to the prediction of the prognosis and follow-up of the disease. The limited evaluable wave formation in the pERG test suggests that pERG does not provide clear results for functional evaluation in RP. Keywords : Optic Disc, Optical Coherence Tomography Angiography, Pattern Electroretinography, Retinal Nerve Fiber Thickness, Retinitis Pigmentosa