2Department of Ophthalmology, Atatürk Educating and Research Hospital, İzmir Katip Çelebi University, İzmir, Türkiye
3Department of Internal Medicine, İzmir Bozyaka Education and Research Hospital, University of Health Sciences, İzmir, Türkiye DOI : 10.37845/ret.vit.2024.33.27 Purpose: The goal of this study is to investigate the effects of vitamin D deficiency in choroidal vacular index (CVI) and choroidal thickness (CT) of the subfoveal and peripapillary area.
Materials and Methods: All macular and peripapillary images were taken by enhanced depth imaging (EDI) mode of spectral domain optical coherence tomography (SD-OCT). The CT was measured at five different points; at the subfovea and at 500?m intervals away from the optic nerve in the superior, inferior, nasal, and temporal quadrants. Choroid images taken from subfoveal and peripapillary region were divided into luminal and stromal areas determined by image binarization method. CVI was defined as the ratio of LA to total choroid area (TCA).
Results: The mean vitamin D levels were 10.58±3.04 ng/mL in Group 1, and 24.92±3.77 ng/mL in Group 2 (p <0.0001). Subfoveal and peripapillary nasal, superior and inferior CT was found to be statistically significantly thinner in Group 1 (p <0.001, all). CVI in subfoveal region, peripapillary nasal and superior quadrants was statistically significantly lower in Group 1 (p=0.001, p=0.012, p=0.011, respectively). There were positive correlations between vitamin D levels and subfoveal CT, nasal, superior, and inferior peripapillary CT ( p < 0.001, p = 0.001, p < 0.001, p < 0.001, respectively) and subfoveal CVI, nasal, and superior peripapillary CVI (p = 0.007, p = 0.007, p = 0.003 respectively).
Conclusion: In individuals with vitamin D deficiency, both CT and CVI may be negatively affected in the subfoveal, peripapillary nasal and superior quadrants..
Keywords : Choroidal thickness, choroidal vascular index, luminal area, stromal area, vitamin D