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¹Beypazarı State Hospital, Ophtalmology, Ankara, Türkiye
²Etlik City Hospital, Ophtalmology, Ankara, Türkiye DOI : 10.37845/ret.vit.2026.35.12 We report a case of peripheral retinal ischemia in a 43-year-old woman receiving long-term systemic chemotherapy with gemcitabine, trastuzumab, and carboplatin for breast cancer. The patient presented with blurred vision in the right eye. Fundus examination revealed bilateral peripheral retinal neovascularization and hemorrhages. Optical coherence tomography demonstrated bilateral thinning of the middle retinal layers, and fluorescein angiography showed extensive peripheral retinal nonperfusion and neovascularization in both eyes. After excluding hematological, biochemical, and inflammatory causes of retinal ischemia, the retinal findings were attributed to drug-induced retinal ischemia. Panretinal photocoagulation was performed, resulting in stabilization of the retinal findings. This case highlights the importance of regular ophthalmic monitoring in patients receiving combination chemotherapy for breast cancer. Keywords : Gemcitabine, trastuzumab, carboplatin, retinal ischemia, peripheral retinal neovascularization