GATA H.Paşa Eğt. Hst. Göz Kl.
60 patients of diabetes mellitus Type I (DM type I) were included to this study. They were classified in three groups on the basis of diabetic retinal pathology. These groups were constituted of 20 patients with any diabetic retinal findings (FT), nonproliferatif diabetic retnopathy (NPDR), or proliferative diabetic retinopathy (PDR), respectively. A variety of HLA types including HLA B7, B8, B12, B13, B14, B15, B18, DR3 and DR4 which were suggested to be associated with DM type I and diabetic retinopathy, were studied in DM cases. When compared with the control group of 60 healthy adults, significantly lower incidence of HLA B7 and higher incidence of HLA B8, DR3, DR4, DR3/4 were incidence of HLA B7 and higher incidence of HLA B8, DR3, DR4, DR3/4 were found in three groups of DM (P<0.05), A significant increasing incidence of HLA DR4 positivity and HLA DR3 negativity was ranged from patients with no retinal pathological finding to those with NPDR and PDR (P<0.05). As a result on the basis of these findings, lower incidence of HLA B7, higher incidence of HLA B8, DR3, DR4, DR3/4 were considered as risk factors in the arising and progression of DM type I also, it was concluded that the development risk of retinopathy incre-ased with the negativity of HLA DR3, while HLA DR4 was positive, in DM type I.
Keywords :
Tip I Diabetes Mellitus, Diabetik Retinopati, Sınıf I HLA, Sınıf II HLA
