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¹Serbest Hekim, Adana, Uz. Dr.
²Çukurova Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Adana, Uz. Dr.
³Çukurova Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Adana, Prof. Dr.
⁴Adana Numune Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Adana, Doç. Dr. Purpose: To evaluate cardiovascular and inflammatory risk factors in Age-Related Macular Degeneration (AMD).
Materials and Methods: Thirty-nine patient with dry-type AMD and 37 control were included in the study. Smoking history, body mass index (BMI), serum fibrinogen CRP, IL-6, Tumour necrosis factor alpha (TNF-alpha), Apolipoprotein B, Lipoprotein A, HDL, LDL and total cholesterol values were analyzed. Cardiologic examination was performed to all participants.
Results: In dry-type AMD patients, the mean BMI (33.1±5.13) were statistically significantly higher than in the control group (24.9±5.63), (p=0.045) . The mean TNF-alfa levels for dry-type AMD and controls were 15.6±52.29 pg/ml and 15.5±41.37 pg/ml, respectively and statistical significant difference was observed (p=0.035). There was statistical significant difference in terms of mean IL-6 levels which were 31.9±114.6 and 1.2±1.5 pg/ml, (p<0.05), respectively. There were no significiant differences between cases and controls in terms of serum fibrinogen, HDL, LDL, total cholesterol, trigliserid, CRP, Lip (a), Apo-B, smoking.
Conclusion: In the study there was no relationship between serum cardiac risk factors and AMD. In addition, there was high rate of obesity in the patient group. In the patient group, TNF alpha and IL-6 levels were higher than the control group. These results suggest that inflammatory factors may have a role in the pathogenesis of AMD. Keywords : Age-related macular degeneration, cardiovascular factors, inflammatory factors