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M.D. Asistant Professor, Baskent University Faculty of Medicine Department of Ophthalmology, Adana/TURKEY It is known that pregnancy is an important risk factor for the development of diabetic retinopathy and diabetic macular edema. In this report the author describes a case of a female patient with diabetes mellitus (DM) type 1 who faced a progress of diabetic retinopathy (DR) during her pregnancy with a development of diabetic macular edema (DME) and a deterioration of visual acuity in the left eye. The patient had been under observation for DR, and she had panretinal argon laser treatment for severe non-proliferative form of DR for two years before pregnancy. During the third trimester of pregnancy, a significant reduction of visual acuity in the patients' left eye occurred as a result of a fast developing DME. The visual acuity of the right eye had already been detoriated before pregnancy because of submacular fibrosis. She received additional peripheral retinal laser photocoagulation. The delivery went without complications. A gradual improvement in VA was expected during the post-delivery period. Unfortunately there was no reduction of DME for postpartum three months. We discussed the option of intravitreal ranibizumab treatment and the patient had three monthly injections which were followed by seven days interruption of breastfeeding. No side effects were observed for the patient and the baby. The patient had an improvement in visual acuity and she is under observation for two years after three injections. Keywords : Intravitreal anti-VEGF treatment, pregnancy, lactation