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¹Erciyes Üni. Tıp Fak. Göz Has. ABD.
²Erciyes Üni. Tıp Fak. İmmünoloji ABD. Frequencies of HLA antigens and their relationship with specific organ involvements in Behçet's disease were investigated. Fourty patients with Behçet's disease between the ages of 15-47 were taken into the study. Eighteen of patients were female and 22 were male. HLA antigens of 50 healthy individuals were taken as control group. Spesific organ involvements of the patients were as follows:aphtous ulcers were present in 92.5%,genital ulcers in 82.5%, ocular involvement in 70%, skin lesions in 87.5%,and joint involvement in 55%. Ocular involvement was mora frequent in males (male/female ratio:2.2/l, chi spuare:4.6,p<0.05). There was sex difference in other organ involvements. The patients had higher frequencies of HLA B51, DR8 and DQ7 and lower frequencies of HLA B18 and DQ2 than the controls.
HLA antigens showed any relationsship with neither specific organ lesions nor sex of the patients. In conclusion, HLA antigens have a role in Behçet's disease but they have no effect on determination of specific organ involvement. Keywords : Behçet's disease, HLA antigens, HLA B51, HLA DR8, HLA DQ7